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Dementia

Mi­croscopy shows de­vel­op­ment of Alzheimer’s plaques

he neu­ropathol­o­gy of Alzheimer’s dis­ease (AD) is char­ac­ter­ized by hy­per­phos­pho­ry­lat­ed tau neu­rofib­ril­lary tan­gles (NFTs) and amy­loid-be­ta (Aβ) plaques. Aβ plaques are hy­poth­e­sized to fol­low a de­vel­op­ment se­quence start­ing with dif­fuse plaques, which evolve in­to more com­pact plaques and fi­nal­ly ma­ture in­to the clas­sic cored plaque type.

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Iden­ti­fy cog­ni­tive im­pair­ment in gait to de­tect alzheimer’s disease

The gait pat­terns of old­er in­di­vid­u­als can cue cog­ni­tive prob­lems and even help di­ag­nose dif­fer­ent types of neu­rode­gen­er­a­tive dis­eases. For ex­am­ple, Alzheimer’s dis­ease could pos­si­bly be iden­ti­fied at an ear­ly stage based on the gait. The way old­er peo­ple walk can be used to en­able ear­ly di­ag­no­sis of dif­fer­ent types of neu­rode­gen­er­a­tive diseases.

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